The movie made an impressive start at the box office with $17.5 million in previews before opening at 4,450 theatres across the U.S.
According to industry analysts, the film is projected to earn between $110 million and $120 million in its opening weekend.
The movie has earned $35 million after opening in 47 international markets, a promising start for the latest instalment in the MCU.
James Gunn created 600 versions of "Guardians of the Galaxy Vol. 3" to take advantage of the multiple aspect ratios available.
James Gunn has announced that this will be his final "Guardians of the Galaxy" film, as he shifts his focus to DC Studios.
Gunn revealed that Rocket's story is at the heart of the final film, which completes his character's story arc.
"Guardians of the Galaxy Vol. 3" began showing in theaters on May 5, providing fans the opportunity to see the final chapter.